New antibiotics could be from fish slime, say scientists

WASHINGTON: Antibiotic resis-tance is a growing danger, with experts warning of a return to a situation where everyday infections could become life-threatening. The NHS is aiming to cut antibiotic use by 15 per cent by 2024 to tackle the problem — which has been called a danger to humanity, while the government has also announced it is looking into offering incentives to drug companies to come up with new antibiotics. Now researchers say new antibiotics might be found in the layer of mucus that coats the outer surface of young fish. While the mucus itself helps protect fish from harmful bacteria, fungi and viruses, the team are interested in the collection of microbes it is home to — the so-called microbiome — and the substances it produces.
“We believe the microbes in the mucus add chemistry to the antiseptic power of the mucus and that new bioactive compounds might be discovered from the fish microbiome,” said Dr Sandra Loesgen, the head of the research group behind the work at Oregon State University. The research, presented at the American Chemical Society spring national meeting in Orlando, Florida, involved the team swabbing 17 species of fish caught off the southern California coast. In total, 47 different strains of bacteria found in the mucus of the fish were grown separately and the cocktails of substances they produced were collected and tested for their antimicrobial prowess.
The team say a number of the strains produced chemical mixtures that were able to tackle the methicillin-resistant Staphylococcus aureus, or MRSA, with a smaller proportion able to tackle E coli. Some also proved effective against the problematic yeast Candida albicans, and even colon cancer cells.
While the team say it is not clear whether the bacteria found are part of the typical surface flora of the fish species, they are now working to unpick which particular substances within the chemical mixtures are behind the antimicrobial effects. — Agencies